CAS No. 1195765-45-7

Molecular Formula: C23H20F3N5O2S2
Molecular Weight: 519.5624096
HS Code: 29350090

Category:Working Standards
Purity:99,38%

Molecular Weight: 519.56
Molecular Formula: C23H20F3N5O2S2
Canonical SMILES: CC(C)(C)C1=NC(=C(S1)C2=NC(=NC=C2)N)C3=C(C(=CC=C3)NS(=O)(=O)C4=C(C=CC=C4F)F)F
InChI: InChI=1S/C23H20F3N5O2S2/c1-23(2,3)21-30-18(19(34-21)16-10-11-28-22(27)29-16)12-6-4-9-15(17(12)26)31-35(32,33)20-13(24)7-5-8-14(20)25/h4-11,31H,1-3H3,(H2,27,28,29)
InChIKey: BFSMGDJOXZAERB-UHFFFAOYSA-N
Boiling Point: 653.7±65.0°C at 760 mmHg
Melting Point: 214-216°C
Purity: >98%
Solubility: Soluble in DMSO, DMF
Application: Antineoplastic Agents
Storage: Store at -20°C
Synonyms: N-[3-[5-(2-Amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-4-thiazolyl]-2-fluorophenyl]-2,6-difluoro-benzenesulfonamide; Dabarefenib; GSK 2118436; Tafinlar
Description
Dabrafenib (GSK2118436) is a mutant BRAFV600 specific inhibitor with IC50 of 0.8 nM, with 4- and 6-fold less potency against B-Raf(wt) and c-Raf, respectively.


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