Molecular Weight: 379.49
Molecular Formula: C24H29NO3
Canonical SMILES: COC1=C(C=C2C(=C1)CC(C2=O)CC3CCN(CC3)CC4=CC=CC=C4)OC
InChI: InChI=1S/C24H29NO3/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18/h3-7,14-15,17,20H,8-13,16H2,1-2H3
InChIKey: ADEBPBSSDYVVLD-UHFFFAOYSA-N
Boiling Point: 527.9±50.0 °C (Predicted)
Melting Point: 207 °C
Purity: > 98%
Solubility: Slightly soluble in Acetone, Chloroform, Water (2.93 mg/L at 25 °C )
Storage: -20 °C
Synonyms: 2,3-Dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one; (±)-E 2020; 1-Benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine; Neuripezil; Tonizep; 2-((1-Benzylpiperidin-4-yl)methyl)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one; Aricept; HSDB 7743; HSDB7743; HSDB-7743; 1-benzyl-4-((5,6-dimethoxy-1-indanon)-2-yl)methylpiperidine hydrochloride; 2-((1-Benzylpiperidin-4-yl)methyl)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one; Eranz; Aricept ODT; donepezilo; donepezilum; CHEMBL502; donepezil hydrochloride; donepezilium oxalate trihydrate; E 2020; E-2020; E2020; 2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one; (RS)-2-[(1-BENZYL-PIPERIDIN-4-YL)METHYL]-5,6-DIMETHOXYINDAN-1-ONE
DescriptionDonepezil, also called Aricept, a centrally acting reversible acetyl cholinesterase inhibitor that the FDA has also approved for the treatment of moderate to severe Alzheimer's disease. It readily crosses the blood-brain barrier to reduce the breakdown of acetylcholine by increasing the concentration of acetylcholine through reversible inhibition of its hydrolysis by acetylcholinesterase.
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