Molecular Weight: 446.90
Molecular Formula: C22H24ClFN4O3
Canonical SMILES: COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)OCCCN4CCOCC4
InChI: InChI=1S/C22H24ClFN4O3/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15/h3-4,11-14H,2,5-10H2,1H3,(H,25,26,27)
InChIKey: XGALLCVXEZPNRQ-UHFFFAOYSA-N
Boiling Point: 586.8±50.0°C (Predicted)
Melting Point: 192-194°C
Purity: >98%
Solubility: Slightly soluble in DMSO, Methanol (Heated)
Storage: Store at -20°C
Synonyms: ZD1839; ZD 1839; ZD-1839; N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-4-quinazolinamine; Iressa; gefitinibum
DescriptionGefitinib is an antineoplastic drug. Gefitinib effectively inhibits all tyrosine phosphorylation sites on EGFR in both the high and low EGFR-expressing cell lines including NR6, NR6M and NR6W cell lines. The phosphorylation sites Tyr1173 and Tyr992 are less sensitive requiring higher concentrations of Gefitinib for inhibition.
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