Molecular Weight: 238.28
Molecular Formula: C15H14N2O
Canonical SMILES: O=C1NC=2C=CC=CC2C1=CC=3NC(=CC3C)C
InChI: InChI=1S/C15H14N2O/c1-9-7-10(2)16-14(9)8-12-11-5-3-4-6-13(11)17-15(12)18/h3-8,16H,1-2H3,(H,17,18)
InChIKey: WUWDLXZGHZSWQZ-UHFFFAOYSA-N
Melting Point: >190°C (dec.)
Purity: 98%
Application: Angiogenesis Inhibitors
Synonyms: SU5416; SU-5416; SU 5416; Sugen 5416; semoxind
DescriptionSemaxinib is a quinolone derivative with potential antineoplastic activity. Semaxinib reversibly inhibits ATP binding to the tyrosine kinase domain of vascular endothelial growth factor receptor 2 (VEGFR2), which may inhibit VEGF-stimulated endothelial cell migration and proliferation and reduce the tumor microvasculature. This agent also inhibits the phosphorylation of the stem cell factor receptor tyrosine kinase c-kit, often expressed in acute myelogenous leukemia cells.
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