CAS No. 34580-14-8

Characters	White to brownish-yellow,fine,crystalline powder.
Identification	TLC IR spectrum
Solubility	Sparingly soluble in water,slightly soluble in methanol,very slightly soluble in acetonifrile
Clarity and colour of solution	Clear and not more than Y4,BY4,B4
Loss on drying	Not more than 0.5%
Sulphated ash	Not more than 0.1%
Related substances(HPLC)
Impurity A	Not more than 0.2%
Impurity G	Not more than 0.2%
Single unknown impurity	Not more than 0.10%
Total impurities	Not more than 0.5%
Residual solvents	Acetone ≤ 5000PPM
Methanol	≤ 500PPM
Assay (potentiometic titration) Calculated on the dried basis	Between 98.5% and 101.0%

Molecular Formula: C23H23NO5S
Molecular Weight: 425.5
Hazard Symbols: Xn,T
WGKGermany: 3
HS Code: 29349990

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Molecular Weight: 425.5
Molecular Formula: C19H19NOS.C4H4O4
Canonical SMILES: CN1CCC(=C2C3=C(C(=O)CC4=CC=CC=C42)SC=C3)CC1.C(=CC(=O)O)C(=O)O
InChI: InChI=1S/C19H19NOS.C4H4O4/c1-20-9-6-13(7-10-20)18-15-5-3-2-4-14(15)12-17(21)19-16(18)8-11-22-19;5-3(6)1-2-4(7)8/h2-5,8,11H,6-7,9-10,12H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1+
InChIKey: YNQQEYBLVYAWNX-WLHGVMLRSA-N
Boiling Point: 250-263 °C(lit.)
Melting Point: >191°C (dec.)
Purity: >98%
Solubility: In Vitro:
DMSO : ≥ 100 mg/mL(235.02 mM)
H2O : 16.67 mg/mL(39.18 mM;Need ultrasonic)
In Vivo:
1.Add each solvent one by one:PBS
Solubility: 37.5 mg/mL (88.13 mM); Clear solution; Need ultrasonic
2.Add each solvent one by one:10% DMSO >> 40%PEG300 >> 5%Tween-80 >> 45% saline
Solubility: ≥ 2.5 mg/mL (5.88 mM); Clear solution
3.Add each solvent one by one:10% DMSO >> 90% (20%SBE-β-CDin saline)
Solubility: ≥ 2.5 mg/mL (5.88 mM); Clear solution
Application: Antipruritics
Storage: 4°C, sealed storage, away from moisture
* In solvent :
-80°C, 6 months
-20°C, 1 month (sealed storage, away from moisture)
Synonyms: Zaditen; Zaditor
Description
Ketotifen is a second-generation noncompetitive H1-antihistamine and mast cell stabilizer. It is most commonly sold as a salt with fumaric acid, ketotifen fumarate, and is available in two forms. In its ophthalmic form, it is used to treat allergic conjunctivitis,or the itchy red eyes caused by allergies. In its oral form, it is used to preventasthma attacks.


More details are to be found on supplier website

Smile code:
O=C(C1=C2C=CS1)CC3=CC=CC=C3C2=C4CCN(C)CC4.O=C(O)/C=C/C(O)=O
MDL Number:
MFCD00079394
Purity :
95%
Available in stock:
37.3 g