Molecular Weight: 194.19
Molecular Formula: C10H10O4
Canonical SMILES: COC(=O)C=CC1=C(C=CC(=C1)O)O
InChI: InChI=1S/C10H10O4/c1-14-10(13)5-2-7-6-8(11)3-4-9(7)12/h2-6,11-12H,1H3/b5-2+
InChIKey: BQCNSTFWSKOWMA-GORDUTHDSA-N
Purity: ≥98% by HPLC
Storage: Store in a cool and dry place (or refer to the Certificate of Analysis).
Synonyms: Methyl 2,5-dihydoxycinnamate; 3-(2,5-dihydroxyphenyl)-2-propenoic acid, methyl ester; Erbstatin Analog
DescriptionMethyl 2,5-dihydroxycinnamate, a stable analog of erbstatin, is a stable, potent inhibitor of EGFR kinase activity. It is described to be four-times more stable than erbstatin in calf serum2. It was shown to delay the S-phase induction by epidermal growth factor in quiescent normal rat kidney cells, without affecting the total amount of DNA synthesis.
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