Molecular Weight: 129.16
Molecular Formula: C6H11NO2
Canonical SMILES: C=CC(CCC(=O)O)N
InChI: InChI=1S/C6H11NO2/c1-2-5(7)3-4-6(8)9/h2,5H,1,3-4,7H2,(H,8,9)
InChIKey: PJDFLNIOAUIZSL-UHFFFAOYSA-N
Boiling Point: 277.7±28.0 °C | Condition: Press: 760 Torr
Melting Point: 209 °C
Purity: ≥98%
Solubility: Soluble in Methanol (Slightly), Water (Slightly)
Application: Vigabatrin is used in combination with other agents as therapy of refractory complex partial seizures and as monotherapy for infantile spasms. It is an antiepileptic drug.
Storage: Store at 2-8°C
Synonyms: γ-Vinyl-GABA; 4-Amino-5-hexenoic Acid; (±)-4-Amino-5-hexenoic Acid; Sabril; Vigabatrine; 4-Aminohexenoic acid; rac-Vigabatrin; (±)-Vigabatrin; (±)-4-Aminohexenoic acid
DescriptionVigabatrin is an analogue of gamma-aminobutyric acid(GABA) and is an irreversible inhibitor of 4-aminobutyrate transaminase. It is used in combination with other agents as therapy of refractory complex partial seizures and as monotherapy for infantile spasms. It is an antiepileptic drug that inhibits the breakdown of GABA by acting as a suicide inhibitor of GABA transaminase (GABA-T). It increases brain concentrations of GABA, an inhibitory neurotransmitter in the CNS, by irreversibly inhibiting enzymes that catabolize GABA or block the reuptake of GABA into glia and nerve endings. It may also work by suppressing repetitive neuronal firing through inhibition of voltage-sensitive sodium channels. It is a racemic compound, and its [S]-enantiomer is pharmacologically active. It has been listed.
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