Molecular Weight: 392.40
Molecular Formula: C22H20N2O5
Canonical SMILES: CCC1=C2CN3C(=CC4=C(C3=O)COC(=O)C4(CC)O)C2=NC5=C1C=C(C=C5)O
InChI: InChI=1S/C22H20N2O5/c1-3-12-13-7-11(25)5-6-17(13)23-19-14(12)9-24-18(19)8-16-15(20(24)26)10-29-21(27)22(16,28)4-2/h5-8,25,28H,3-4,9-10H2,1-2H3/t22-/m0/s1
InChIKey: FJHBVJOVLFPMQE-QFIPXVFZSA-N
Boiling Point: 810.3±65.0°C (Predicted)
Melting Point: >169°C (dec.)
Purity: ≥95%
Solubility: Soluble in DMSO (Slightly, Sonicated), Methanol (Slightly, Heated, Sonicated)
Application: the treatment of colorectal cancer
Storage: -20 - 0°C in dark, sealed.
Synonyms: (4S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)dione; 10-Hydroxy-7-ethylcamptothecin; SN 38 Lactone; Irinotecan EP Impurity E; SN-38; USP Irinotecan Related Compound B; Irinotecan Related Compound B; Irinotecan EP Impurity E; NSC-673596
DescriptionAn impurity of Irinotecan, a Topoisomerase I inhibitor used for the treatment of colon cancer and small cell lung cancer. It inhibits DNA and RNA synthesis with IC50s of 0.077 and 1.3 μM, respectively.
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