CAS No. 871038-72-1

Molecular Formula: C20H20FN6O5.K
Molecular Weight: 482.511
HS Code: 2934990002

Molecular Weight: 482.514
Molecular Formula: C20H20FKN6O5
Canonical SMILES: CC1=NN=C(O1)C(=O)NC(C)(C)C2=NC(=C(C(=O)N2C)[O-])C(=O)NCC3=CC=C(C=C3)F.[K+]
InChI: InChI=1S/C20H21FN6O5.K/c1-10-25-26-17(32-10)16(30)24-20(2,3)19-23-13(14(28)18(31)27(19)4)15(29)22-9-11-5-7-12(21)8-6-11;/h5-8,28H,9H2,1-4H3,(H,22,29)(H,24,30);/q;+1/p-1
InChIKey: IFUKBHBISRAZTF-UHFFFAOYSA-M
Melting Point: 155-157°C (dec.)
Purity: 98%
Solubility: In Vitro:
H2O: 25 mg/mL (51.81 mM; Need ultrasonic)
DMSO : 6 mg/mL (12.43 mM; Need ultrasonic)
In Vivo:
1.Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 0.6 mg/mL (1.24 mM); Clear solution
2.Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline
Solubility: ≥ 0.6 mg/mL (1.24 mM); Clear solution
3.Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)
Solubility: ≥ 0.6 mg/mL (1.24 mM); Clear solution
Application: Anti-HIV Agents
Storage: Powder:
-20°C: 3 years
4°C: 2 years
In solvent:
-80°C: 6 months
-20°C: 1 month
Synonyms: MK-0518; MK 0518; MK0518; Raltegravir
Description
Raltegravir is a potent, selective, and orally bioavailable inhibitor of HIV integrase (IC50 = 15 nM). It is metabolized primarily by uridine diphosphate glucuronosyltransferase 1A. Raltegravir has long-term efficacy and safety in managing HIV-1 infection in adults, children, and adolescents.


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