BGC > Produktsuche > N-Desmethyl enzalutamide | 1242137-16-1

Molecular Formula: C20H14F4N4O2S
Molecular Weight: 450.4093728

Description:
N-desmethyl Enzalutamide is a major metabolite of Enzalutamide. Enzalutamide is an androgen-receptor (AR) antagonist (IC50 = 36 nM) in LNCaP cells that inhibits the transcriptional activity of a mutant AR protein. Enzalutamide resists against induction of prostate-specific antigen (PSA) and transmembrane serine protease 2 (TMPRSS2). N-desmethyl Enzalutamide can be used for the treatment of disorders involving androgen, estrogen and progesterone receptors.

• Molecular Weight:450.412
• Melting Point:>230ºC (dec.)

Molecular Formula:
C20H14F4N4O2S
Canonical SMILES:
CC1(C(=O)N(C(=S)N1C2=CC(=C(C=C2)C(=O)N)F)C3=CC(=C(C=C3)C#N)C(F)(F)F)C
InChI:
InChI=1S/C20H14F4N4O2S/c1-19(2)17(30)27(11-4-3-10(9-25)14(7-11)20(22,23)24)18(31)28(19)12-5-6-13(16(26)29)15(21)8-12/h3-8H,1-2H3,(H2,26,29)
InChIKey:
JSFOGZGIBIQRPU-UHFFFAOYSA-N
Solubility:
10 mM in DMSO
Appearance:
Off-white to white powder
Application:
the treatment of disorders involving androgen, estrogen and progesterone receptors
Storage: -20ºC Freeze
Synonyms:
N-desmethylenzalutamide; 1242137-16-1; 4-{3-[4-cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl}-2-fluorobenzamide; 4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-2-fluorobenzamide; Enzalutamide metabolite